Since the 2020s, what the International Monetary Fund calls “global economic fragmentation” (GEF) has intensified, marked by weakening trade coordination, the return of protectionism, and the increasing alignment of trade flows with geopolitical blocs. Key drivers include the war in Ukraine, the long tail of the COVID-19 pandemic, escalating China-US tensions, structural transformations such as the rise of digital services and the green transition, and most recently the second Trump administration’s weaponization of tariffs. The countries of Central and Eastern Europe (CEE) are particularly exposed to the GEF. They benefited substantially from past waves of globalization, building growth models centered on foreign direct investment (FDI), integration into global supply chains, and high export dependence, especially toward Western Europe.